Quadro M4000 vs RTX PRO 4500 SE: Specs, VRAM & Price
Short answer: choose the RTX PRO 4500 SE when 32 GB of VRAM is the gating requirement. Choose the Quadro M4000 when 8 GB is enough for the workload and the lower hourly rate points that way.
The Quadro M4000 has 8 GB of VRAM; the RTX PRO 4500 SE has 32 GB.
You can rent both by the hour, no purchase required. Quadro M4000 from $0.069/GPU/hr; RTX PRO 4500 SE from $0.792/GPU/hr. The Quadro M4000 is 91% cheaper at the entry rate.
Quadro M4000
Good for inference workloads on older-generation hardware
RTX PRO 4500 SE
Good for inference and light fine-tuning workloads
Last updated: 2026-10-10 22:55:30 UTCRefreshes hourly
Specs side by side
| Spec | Quadro M4000 | RTX PRO 4500 SE |
|---|---|---|
| VRAM | 8 GB | 32 GB |
| Architecture | Maxwell | Blackwell |
| Compute capability | 5.2 | 12.0 |
| Precisions in hardware | FP32, FP16 | FP32, FP16, BF16, FP8, INT4 |
| Form factor | PCIe | – |
| Regions | 1 | 1 |
On-demand price
| Rate | Quadro M4000 | RTX PRO 4500 SE |
|---|---|---|
| Lowest per GPU/hr | $0.069/GPU/hr (cheapest overall) | $0.792/GPU/hr |
Which is better for AI: Quadro M4000 or RTX PRO 4500 SE?
Choose the RTX PRO 4500 SE when 32 GB of VRAM is the gating requirement. Choose the Quadro M4000 when 8 GB is enough for the workload and the lower hourly rate points that way.
Quadro M4000 vs RTX PRO 4500 SE: common questions
Is the Quadro M4000 or the RTX PRO 4500 SE better for AI?
Short answer: choose the RTX PRO 4500 SE when 32 GB of VRAM is the gating requirement. Choose the Quadro M4000 when 8 GB is enough for the workload and the lower hourly rate points that way.
Is the Quadro M4000 or the RTX PRO 4500 SE cheaper to rent?
On Aquanode's live marketplace the Quadro M4000 starts at $0.069/GPU/hr (median $0.069/GPU/hr) and the RTX PRO 4500 SE starts at $0.792/GPU/hr (median $0.792/GPU/hr). The Quadro M4000 is the cheaper of the two at the entry rate, by 91%.
What is the difference between the Quadro M4000 and the RTX PRO 4500 SE?
The Quadro M4000 has 8 GB of VRAM against the RTX PRO 4500 SE's 32 GB; the Quadro M4000 is a Maxwell part and the RTX PRO 4500 SE is Blackwell (compute capability 5.2 vs 12.0); only the RTX PRO 4500 SE supports BF16, FP8, INT4 compute. On price, the Quadro M4000 lists from $0.069/GPU/hr and the RTX PRO 4500 SE from $0.792/GPU/hr.
How widely available are the Quadro M4000 and the RTX PRO 4500 SE?
The Quadro M4000 is listed in 1 region and the RTX PRO 4500 SE in 1 region right now.
How much does 1,000 GPU-hours cost on the Quadro M4000 vs the RTX PRO 4500 SE?
At the lowest rates listed today, 1,000 GPU-hours costs $69 on the Quadro M4000 and $792 on the RTX PRO 4500 SE, a difference of $723 for the same runtime. Rates are per GPU per hour and update hourly.
How much VRAM does the Quadro M4000 have compared to the RTX PRO 4500 SE?
The Quadro M4000 has 8 GB of VRAM; the RTX PRO 4500 SE has 32 GB.
How this comparison is calculated
Every price is normalized to a per-GPU hourly rate using the same pipeline as every other pricing surface on Aquanode, and only the cheapest qualifying offer per provider is shown. A dash means that provider does not currently list that GPU.
Architecture, compute capability and supported precisions come from each vendor's published datasheet for that generation, not from the marketplace feed. This page regenerates at most once per hour.
Memory bandwidth, tensor TFLOPS, NVLink/interconnect and max board power are the same verified-from-datasheet figures shown on each model's own Quadro M4000 page and RTX PRO 4500 SE page, which link the primary vendor source for that model. A dash here means Aquanode hasn't verified that figure from a primary source yet, never a guess.
Go further
Check what fits in each card's memory with the Quadro M4000 VRAM calculator and the RTX PRO 4500 SE VRAM calculator, or browse every model by generation in the GPU index.
More Quadro M4000 comparisons
More RTX PRO 4500 SE comparisons
Related reading: H100 pricing and specs, H100 vs H200, A100 vs H100, H100 and H200: SXM vs NVL vs PCIe, and The best GPUs for AI, ranked.
