LLM

How to deploy Qwen3.5-397B-A17B on a GPU cloud

A 403B (MoE) language model for chat and instruction-following. Full specs, license and use cases.

Qwen3.5-397B-A17B size and hardware requirements

403.4B
Total parameters
~17B active per token (mixture-of-experts; see total parameters above)
Active parameters
BF16
Published precision
901.7 GB
Min VRAM (native)
PrecisionWeight size on diskRequired VRAMCheapest live fitGPUs neededEst. $/hr (full fit)
BF16751.4 GB901.7 GBNo capable live offer found––
FP8 (quantized)375.7 GB450.8 GBRTX PRO 60005$8.20/hr
INT4 (quantized)187.8 GB225.4 GBRTX A60005$1.65/hr

How to run Qwen3.5-397B-A17B

Run Qwen3.5-397B-A17B with vLLM

Generic example, not from the model's own docs: adjust flags (quantization, context length, parallelism) for your setup.

vllm serve Qwen/Qwen3.5-397B-A17B --tensor-parallel-size 1

Run Qwen3.5-397B-A17B with Ollama

Verified against Ollama's own library listing.

ollama run qwen3.5:397b

Source: https://ollama.com/library/qwen3.5:397b

Run Qwen3.5-397B-A17B with GGUF quantizations

Prebuilt GGUF weights published at unsloth/Qwen3.5-397B-A17B-GGUF. Run with llama.cpp's llama-server or load the repo directly in LM Studio.

llama-server -hf unsloth/Qwen3.5-397B-A17B-GGUF

Source: https://huggingface.co/unsloth/Qwen3.5-397B-A17B-GGUF

Deploy Qwen3.5-397B-A17B on Aquanode

Aquanode has no one-click deploy template for Qwen3.5-397B-A17B; you install the inference engine yourself with the commands below. Aquanode sells GPU pods billed per second, not a hosted inference API.

  1. Launch a bare GPU pod sized to the requirement above (902 GB VRAM or more).
  2. Open a terminal on the pod, or save one of the commands above as a startup script so it runs automatically the first time the pod boots.
  3. Run the command and connect to the resulting endpoint.

Submit the job. Everything after that is ours.

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