AMD MI300X vs RTX PRO 6000 SE: Specs, VRAM & Price
Short answer: choose the AMD MI300X when 192 GB of VRAM is the gating requirement. Choose the RTX PRO 6000 SE when 96 GB is enough for the workload and the lower hourly rate points that way.
The AMD MI300X has 192 GB of VRAM; the RTX PRO 6000 SE has 96 GB.
You can rent both by the hour, no purchase required. AMD MI300X from $2.63/GPU/hr; RTX PRO 6000 SE from $2.15/GPU/hr. The RTX PRO 6000 SE is 18% cheaper at the entry rate.
AMD MI300X
Good for training and serving frontier-scale LLMs
RTX PRO 6000 SE
Good for training and serving frontier-scale LLMs
Last updated: 2026-10-10 19:56:33 UTCRefreshes hourly
Specs side by side
| Spec | AMD MI300X | RTX PRO 6000 SE |
|---|---|---|
| VRAM | 192 GB | 96 GB |
| Memory bandwidth | 5.3 TB/s | 1,597 GB/s |
| Architecture | CDNA3 | Blackwell |
| Compute capability | n/a | 12.0 |
| Precisions in hardware | FP32, FP16, BF16, FP8, INT4 | FP32, FP16, BF16, FP8, INT4 |
| Peak FP16/BF16 tensor TFLOPS | 1,307.4 TFLOPS | – |
| Peak FP8 tensor TFLOPS | 2,614.9 TFLOPS | – |
| NVLink / multi-GPU interconnect | Infinity Fabric | – |
| Max board power (TDP) | 750W | Up to 600W (configurable) |
| Form factor | – | PCIe |
| Regions | 2 | 1 |
On-demand price
| Rate | AMD MI300X | RTX PRO 6000 SE |
|---|---|---|
| Lowest per GPU/hr | $2.63/GPU/hr | $2.15/GPU/hr (cheapest overall) |
Which is better for AI: AMD MI300X or RTX PRO 6000 SE?
Choose the AMD MI300X when 192 GB of VRAM is the gating requirement. Choose the RTX PRO 6000 SE when 96 GB is enough for the workload and the lower hourly rate points that way.
AMD MI300X vs RTX PRO 6000 SE: common questions
Is the AMD MI300X or the RTX PRO 6000 SE better for AI?
Short answer: choose the AMD MI300X when 192 GB of VRAM is the gating requirement. Choose the RTX PRO 6000 SE when 96 GB is enough for the workload and the lower hourly rate points that way.
Is the AMD MI300X or the RTX PRO 6000 SE cheaper to rent?
On Aquanode's live marketplace the AMD MI300X starts at $2.63/GPU/hr (median $2.63/GPU/hr) and the RTX PRO 6000 SE starts at $2.15/GPU/hr (median $2.15/GPU/hr). The RTX PRO 6000 SE is the cheaper of the two at the entry rate, by 18%.
What is the difference between the AMD MI300X and the RTX PRO 6000 SE?
The AMD MI300X has 192 GB of VRAM against the RTX PRO 6000 SE's 96 GB; the AMD MI300X is a CDNA3 part and the RTX PRO 6000 SE is Blackwell; both run BF16, FP8, INT4 workloads in hardware. On price, the AMD MI300X lists from $2.63/GPU/hr and the RTX PRO 6000 SE from $2.15/GPU/hr.
How widely available are the AMD MI300X and the RTX PRO 6000 SE?
The AMD MI300X is listed in 2 regions and the RTX PRO 6000 SE in 1 region right now.
How much does 1,000 GPU-hours cost on the AMD MI300X vs the RTX PRO 6000 SE?
At the lowest rates listed today, 1,000 GPU-hours costs $2,629 on the AMD MI300X and $2,148 on the RTX PRO 6000 SE, a difference of $481 for the same runtime. Rates are per GPU per hour and update hourly.
How much VRAM does the AMD MI300X have compared to the RTX PRO 6000 SE?
The AMD MI300X has 192 GB of VRAM; the RTX PRO 6000 SE has 96 GB.
Does the AMD MI300X or the RTX PRO 6000 SE support NVLink?
The AMD MI300X supports Infinity Fabric; the RTX PRO 6000 SE has no dedicated GPU-to-GPU interconnect.
How this comparison is calculated
Every price is normalized to a per-GPU hourly rate using the same pipeline as every other pricing surface on Aquanode, and only the cheapest qualifying offer per provider is shown. A dash means that provider does not currently list that GPU.
Architecture, compute capability and supported precisions come from each vendor's published datasheet for that generation, not from the marketplace feed. This page regenerates at most once per hour.
Memory bandwidth, tensor TFLOPS, NVLink/interconnect and max board power are the same verified-from-datasheet figures shown on each model's own AMD MI300X page and RTX PRO 6000 SE page, which link the primary vendor source for that model. A dash here means Aquanode hasn't verified that figure from a primary source yet, never a guess.
Go further
Check what fits in each card's memory with the AMD MI300X VRAM calculator and the RTX PRO 6000 SE VRAM calculator, see vendor-published throughput in the GPU benchmarks and specs table, or browse every model by generation in the GPU index.
More AMD MI300X comparisons
More RTX PRO 6000 SE comparisons
Related reading: AMD MI300X pricing and specs, ROCm vs CUDA, AMD vs NVIDIA GPUs for AI, AMD MI355X guide, and The best GPUs for AI, ranked.
