What GPU do I need to run google/medgemma-27b-it?

28.8B parameters, published in BF16. View on Hugging FaceGated

28.8B
Parameters
BF16
Native precision
Gemma3ForConditionalGeneration
Architecture
image-text-to-text
Pipeline

medgemma-27b-it is published by google on Hugging Face, with 277,058 downloads and 418 likes to date. It's a Gemma3ForConditionalGeneration model built for image-text-to-text, published natively in BF16, and gated: you'll need to accept the model's terms on Hugging Face before downloading weights.

VRAM required & cheapest live GPU fit

Required VRAM = weight size at each precision, plus a fixed overhead for KV-cache, activations, and fragmentation. Full formula and assumptions: methodology.

Precision
Weight size
Required VRAM
Cheapest live fit
GPUs needed
Est. $/hr (full fit)
BF16
53.7 GB
64.5 GB
A100 (runpod)
1
$1.19/hr
cheaper alt.
RTX 4070 (simplepod)
6
$0.480/hr
FP8 (quantized)
26.9 GB
32.2 GB
L40 (massecompute)
1
$0.772/hr
cheaper alt.
RTX 4070 (simplepod)
3
$0.240/hr
INT4 (quantized)
13.4 GB
16.1 GB
RTX 3090 (simplepod)
1
$0.160/hr
cheaper alt.
RTX 3080 (simplepod)
2
$0.140/hr

A GPU is only matched to a row if its hardware supports that precision, and the primary recommendation is always a single-GPU fit when one exists.

INT4 caveat: requires a quantized checkpoint actually published for this model, check its Hugging Face page before relying on this row.

Cheapest way to run medgemma-27b-it at its published (BF16) precision: 1× A100 on runpod, at $1.19/hr per GPU ($1.19/hr total). Quantizing to FP8 or INT4 (rows above) can cost less, but requires a compatible quantized checkpoint to exist for this model.

Weight-to-VRAM math, the fit rules, and how live prices are normalized: full methodology.

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